Heparin-binding EGF-like growth factor (HB-EGF) is a 12/xad16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF/xadlike domain, and a heparin-binding motif. Mature HB/xadEGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB/xadEGF shows 76% and 73% aa sequence identity with rat and mouse HB/xadEGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation, it is mitogenic for fibroblasts, but not endothelial cells. HB/xadEGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non/xadmitogenic actions, while EGFR binding induces both mitogenic and non/xadmitogenic activity.
Greater than 95% as determined by reducing SDS-PAGE
Application Notes:
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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