Receptor Tyrosine Kinaselike Orphan Receptor 2(ROR2) belongs to the protein kinase superfamily, Tyr protein kinase family and ROR subfamily. It is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the development of the central nervous system. ROR2 promotes osteogenesis, binds YWHAB and Interacts with WTIP. ROR2 is broadly expressed during embryonic development and can be found in cells of all three germ layers as well as in most organ tissues. Activation of ROR2 signaling promotes cellular proliferation, differentiation, cellpolarization, and migration. ROR2 has also been shown to have very little tyrosine kinase activity in vitro and may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
Greater than 95% as determined by reducing SDS-PAGE
Application Notes:
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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