Recombinant Human GITR (C-mFc)

Product Overview

• Article Name: Recombinant Human GITR (C-mFc)
• Biozol Catalog Number: EKL-PHH2039
• Supplier Catalog Number: PHH2039
• Alternative Catalog Number: EKL-PHH2039-10UG,EKL-PHH2039-50UG,EKL-PHH2039-500UG
• Manufacturer: EnkiLife
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Alternative Names: Tumor necrosis factor receptor superfamily member 18, TNFRSF18, Glucocorticoid-induced TNFR-related protein, CD357, TNFRSF18, AITR, GITR

Product Description

Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA,isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Product Properties

• Molecular Weight: 41.1 KDa
• NCBI: 9
• Purity: Greater than 95% as determined by reducing SDS-PAGE

Application Notes

• Application Notes: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.