Recombinant Human TSLPR&IL-7RA Heterodimer (C-6His)

Product Overview

• Article Name: Recombinant Human TSLPR&IL-7RA Heterodimer (C-6His)
• Biozol Catalog Number: EKL-PHH2398
• Supplier Catalog Number: PHH2398
• Alternative Catalog Number: EKL-PHH2398-10UG,EKL-PHH2398-50UG,EKL-PHH2398-500UG
• Manufacturer: EnkiLife
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Alternative Names: Cytokine receptor-like factor 2, Cytokine receptor-like 2, TSLP receptor, CRL2, ILXR, TSLPR, Interleukin-7 receptor subunit alpha, IL-7R subunit alpha, IL-7RA, CD127

Product Description

The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common gamma receptor-like chain (TSLPR-gamma) and a common interleukin 7 (IL-7) Ralpha chain that belongs to the type 1 cytokine receptor family. IL-7 and IL-7Ralpha bind the gamma(c) receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. TSLP, forming a triple complex of TSLP/TSLPR/IL-7Ralpha, activates JAK1 and JAK2, thereby resulting in phosphorylation of STAT5A and STAT5B, as well as STAT1, STAT3, and other STAT proteins to a lesser extent, and MAPKs and NF-kappaB depending on the cell type.

Product Properties

• Molecular Weight: 54.1 KDa
• NCBI: 9
• Purity: Greater than 95% as determined by reducing SDS-PAGE

Application Notes

• Application Notes: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.