Recombinant Cynomolgus TIM-3 (C-Fc), Human

Product Overview

• Article Name: Recombinant Cynomolgus TIM-3 (C-Fc), Human
• Biozol Catalog Number: EKL-PHV1652
• Supplier Catalog Number: PHV1652
• Alternative Catalog Number: EKL-PHV1652-10UG,EKL-PHV1652-50UG,EKL-PHV1652-500UG
• Manufacturer: EnkiLife
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Monkey
• Alternative Names: T cell immunoglobulin and mucin domain3, HAVCR2, Tim-3, TIM3

Product Description

T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.

Product Properties

• Molecular Weight: 46.3 KDa
• NCBI: 7
• Purity: Greater than 95% as determined by reducing SDS-PAGE

Application Notes

• Application Notes: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.