Sir Two Inhibitor Naphthol, 2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide
Specific cell permeable inhibitor of the sirtuin family of NAD-dependent deacetylases (ySir2: IC50=48µM, hSIRT1: IC50=60µM, hSIRT2: IC50=58µM) with no effect on human HDAC1. Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50=25µM)
Molecular Weight:
394.5
Purity:
97% (HPLC)
CAS Number:
[410536-97-9]
Formula:
C26H22N2O2
Target:
SIRT
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