A potent cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50= ~3 nM in NIH 3T3-derived Shh-
Molecular Weight:
490.1
Purity:
95% (HPLC)
CAS Number:
[912545-86-9]
Formula:
C28H28ClN3OS
Target:
Smoothened
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