1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile, JNK Inhibitor V
Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-alpha plasma levels induced by LPS in mice.
Molecular Weight:
372.5
Purity:
95% (HPLC)
CAS Number:
[345987-15-7]
Formula:
C20H16N6S
Target:
Jnk1, Jnk2, Jnk3
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