Potent and selective inhibitor of MAPK (ERK kinase 1, MEK1) activation (IC50=300nM in vitro, IC50=2nM in vivo). Suppresses activation of MAPK but does not block its activity. Strongly suppresses growth of human implanted colon tumors in mice.
Molecular Weight:
478.7
Source:
Synthetic.
Purity:
95% (HPLC)
CAS Number:
[212631-79-3]
Formula:
C17H14ClF2IN2O2
Target:
MEK1
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