Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROalpha-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV
Molecular Weight:
352.1
Purity:
98% (HPLC)
CAS Number:
[182498-32-4]
Formula:
C13H10BrN3O4
Target:
CXCR2, CXCR1
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