Potent antitumor agent. Inhibitor of DNA-topoisomerase I. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cells. Inhinbits Tat-mediated transactivation of HIV
Molecular Weight:
348.4
Source:
Isolated from Camptotheca acuminata seeds.
Purity:
98% (HPLC)
CAS Number:
[7689-03-4]
Formula:
C20H16N2O4
Target:
Topoisomerase I, p53
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