Model apoptosis inducer. Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10µM), CDK5/p25 (IC50=4nM), GSK-3beta (IC50=15nM), Pim-1 kinase
Molecular Weight:
466.5
Source:
Isolated from Streptomyces staurosporeus.
Purity:
99% (HPLC)
CAS Number:
[62996-74-1]
Formula:
C28H26N4O3
Target:
PKC, CDK1, Topoisomerase II, MLCK
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