Physiologically active metabolite of the immunosuppressive drug leflunomide (Prod. No. ALX-430-095). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-kappaB activation in a dose- and time-dependent
Molecular Weight:
270.2
Purity:
98% (HPLC)
CAS Number:
[108605-62-5]
Formula:
C12H9F3N2O2
Target:
Dihydrorotate dehydrogenase
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