Active metabolite of sulindac (Prod. No. ALX-430-105). Inhibits cyclooxygenase. More selective for PGHS-1 (ID50=0.5 µM) over PGHS-2 (ID50=14 µM). Induces apoptosis by a cyclooxygenase-independent mechanism. Inhibits colorectal cancer growth and gamma-secreta
Molecular Weight:
340.4
Purity:
99% (TLC)
CAS Number:
[32004-67-4]
Formula:
C20H17FO2S
Target:
COX-1, gamma-Secretase, NF-kappaB
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