Potent and selective inhibitor of CDKs. Selective for CDK1/cyclin B kinase (IC50=450nM) [2], CDK2 (IC50=700nM) [4] and CDK5/p35 (IC50=160nM) [4,5]. More potent than olomoucine (Prod. No. BML-CC200). Inhibits M phase promoting factor (MPF) kinase activity
Molecular Weight:
354.4
Purity:
95% (HPLC, TLC)
CAS Number:
[186692-46-6]
Formula:
C19H26N6O
Target:
CDK1, CDK2, CDK5
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