A potent inhibitor of glycogen synthase kinase-3beta (IC50=22 nM). Also inhibits CDK1 (p34cdc2, IC50=180 nM) and CDK5 (IC50=100 nM). It reversibly arrests asynchronous HBL-100 cells at G2. Induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM).
Molecular Weight:
277.3
Purity:
98%
CAS Number:
[160807-49-8]
Formula:
C16H11N3O2
Target:
CDK1, CDK5, GSK-3beta
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