L-663,536, 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid . Na
Inhibitor of PPARalpha activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50s for leukotriene biosynthesis: 2.5 nM in intact leukocyte
Molecular Weight:
494
Purity:
98% (HPLC)
CAS Number:
[118414-82-7]
Formula:
C27H33ClNO2SNa
Target:
FLAP, PPARalpha
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