Potent, ATP-competitive and cell permeable inhibitor of tyrosine kinases (VEGF-R2 IC50=27nM, PDGF-Rbeta IC50=3nM). Also inhibits wild-type and all mutant forms of Kit in mast cells (IC50s=10 to 100nM) resulting in cell cycle arrest and apoptosis. Su11652 wa
Molecular Weight:
414.9
Purity:
98% (HPLC)
CAS Number:
[326914-10-7]
Formula:
C22H27ClN4O2
Target:
VEGFR, PDGFR
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