Antitumor reagent. Topoisomerase II inhibitor. Induces apoptosis by FasL. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells.
Molecular Weight:
588.6
Source:
Semisynthetic derivative of podophyllotoxin.
Purity:
95% (HPLC)
CAS Number:
[33419-42-0]
Formula:
C29H32O13
Target:
Topoisomerase II, p53
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