CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[MEM-129]
Isotype:
Mouse IgM
Buffer:
Tris buffered saline (TBS), pH 8.0
Storage:
2°C to 8°C
Target:
CD59
Antibody Type:
Monoclonal Antibody
Application Notes:
Functional application: The antibody MEM-129 activates T cells. Flow cytometry: Recommended dilution: 1-4 µg/ml.
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