Whole hairy cell leukemia cells and membrane preparation
CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[S-HCL-1]
Isotype:
Mouse IgG2b kappa
Buffer:
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
