Leukocytes of pacient suffering from a LGL-type leukemia.
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumour cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[MEM-53]
Isotype:
Mouse IgG1
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage:
2°C to 8°C
Target:
CD53
Antibody Type:
Monoclonal Antibody
Application Notes:
Immunohistochemistry (frozen sections): It is suitable for discrimination of lymphomas from other tumors. Flow cytometry: Recommended dilution: 1-5 µg/ml.
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