CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[MEM-188]
Isotype:
Mouse IgG2a
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage:
2°C to 8°C
Target:
CD56
Antibody Type:
Monoclonal Antibody
Application Notes:
Flow cytometry: Recommended dilution: 3 µg/ml. Immunohistochemistry (paraffin sections): Recommended dilution: 1:50, pretreatment: heat retrieval (microwave oven) in citrate buffer, standard ABC visualization, positive tissue: membrane-specific reaction in adjacent peripheral nerve, staining of paraprostatic autonomic ganglion.
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