HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[MEM-E/02]
Isotype:
Mouse IgG1
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage:
2°C to 8°C
Target:
HLA-E
Antibody Type:
Monoclonal Antibody
Application Notes:
Immunohistochemistry (paraffin sections): Recommended dilution: 5-10 µg/ml, positive control: human placenta, heat antigen retrieval (sodium citrate), incubation with mAb: 1 hour / RT, detection DAB.
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