A fusion protein representing amino acids 171-356 of human BLNK.
SLP65 / BLNK (SH2 domain-containing leukocyte-specific phosphoprotein of 65 kDa, B cell linker protein), also known as BASH, is an adaptor protein that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). Phosphorylated by Syk tyrosine kinase, SLP65 serves as a scaffold for Btk tyrosine kinase, Vav1 guanine nucleotide exchange factor, phospholipase C gamma2, as well as Grb2 and Nck adaptor proteins, thus represents a central linker protein that bridges the BCR-associated kinases with a multitude of signaling pathways.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[PAb 411]
Isotype:
Rabbit polyclonal
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage:
2°C to 8°C
Target:
Blnk
Antibody Type:
Monoclonal Antibody
Application Notes:
Western blotting: Reducing conditions.
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