The C-reactive protein (CRP) is a cyclic pentameric pentraxin family acute phase protein composed of five identical noncovalently bound nonglycosylated subunits (each subunit 24 kDa, physiologic CRP molecule 117,5 kDa). CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes occuring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.) and is also believed to play an important role in innate immunity. Patients with elevated basal levels of CRP are at increased risk for hypertension and cardiovascular disease.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
C5
Isotype:
Mouse IgG2a
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage:
2°C to 8°C
Target:
CRP
Antibody Type:
Monoclonal Antibody
Application Notes:
ELISA: The antibody C5 has been tested as the capture antibody in a sandwich ELISA for analysis of human C-Reactive Protein in combination with the antibody C7 (cat. no. 1B-484-C100).
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