Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
The guanine nucleotide exchange factor Sos (son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[SOS-01]
Isotype:
Mouse IgG1
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage:
2°C to 8°C
Target:
SOS
Antibody Type:
Monoclonal Antibody
Application Notes:
Western blotting: Recommended dilution: 1 µg/ml, positive control: HeLa human cervix carcinoma cell line, reducing conditions.
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