Histone deacetylase 6 (HDAC6), like other histone deacetylases, affects gene expression by regulation of chromatin remodeling. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. Besides histones, HDAC6 deacetylates also other substrates including alpha tubulin and HSP90 alpha, and is involved in protein trafficking and degradation, as well as in affecting of cell shape and migration. Deregulation of HDAC6 expression and activity is associated with many diseases.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[3D2]
Isotype:
Mouse IgG1 kappa
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Target:
HDAC6
Antibody Type:
Monoclonal Antibody
Application Notes:
Western blotting: Recommended dilution: 1-5 µg/ml.Immunocytochemistry: Recommended dilution: 5-10 µg/ml.
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