PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent, and subsequently PPM1D negatively regulates the p53-mediated transcription, thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas, and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[7E11/C5]
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
