CD118 (LIFR alpha) is a type I transmembrane glycoprotein of the cytokine receptor family, which associates noncovalently with CD130 to form the functional high affinity LIF receptor, which also acts as an oncostatin M receptor. CD118 alone binds LIF with low affinity. A secreted form of CD118 results from alternative splicing, and may have inhibitory effect, as it also binds LIF, although with low affinity. CD118 is not expressed on lymphocytes, but it is widely expressed outside the immune system. Soluble CD118 level rises during pregnancy, in parallel with a drop in circulating LIF levels.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[12D3]
Isotype:
Mouse IgG1 kappa
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Target:
CD118
Antibody Type:
Monoclonal Antibody
Application Dilute:
Flow cytometry: Recommended dilution: 2-5 µg/ml.
Application Notes:
Flow cytometry: Recommended dilution: 2-5 µg/ml.
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