TCR alpha V24-J18 chain is a marker of invariant NK T cells (iNKT). This chain pairs mostly with TCR beta V11 chain, and together they interact with glycolipide-loaded CD1d. This interaction results in iNKT activation and cytokine production (IFN gamma, IL-4, IL-13), which takes important part in immune regulation and host response to pathogens and cancer(support of both Th1 and Th2 way), although iNKT cells represent less than 1% of total peripheral T cells.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[6B11]
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Target:
TCR Valpha24-Jalpha18
Application Notes:
Flow cytometry: Recommended dilution: 1-5 µg/ml
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