SIGLEC10 extracellular domain fused with human IgG1 Fc fragment
SIGLEC10 is a CD33-related receptor of sialoglycans, expressed on eosinophils, monocytes, a subpopulation of NK cells, and at lower level on B cells. Its murine ortholog is Siglec G. SIGLEC10 seems to act as an immunomodulatory receptor, which binds to VAP-1, a glycoprotein expressed on endothelium under inflammatory conditions. Another ligand of SIGLEC10 is CD24, a marker of poorer prognosis in carcinomas.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[5G6]
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Target:
SIGLEC10
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