Fusion protein of human CD207 extracellular part and IgG Fc fragment
CD207 is a 40 kDa type II transmembrane glycoprotein of the C-type lectin family. It binds to mannose-bearing glycoproteins and glycolipids of microbial and viral antigens, including HIV gp120. CD207 is expressed only in Langerhans cells, which are immature dendritic cells of the epidermis and mucosa, and its expression decreases during Langerhans cells maturation. Upon antigen binding CD207 localizes to the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed membranes, which leads to a nonclassical antigen-processing pathway.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[2G3]
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Target:
CD207
Application Notes:
Flow cytometry: Recommended dilution: 0.5-4 µg/ml. Extracellular and intracellular staining.
* VAT and and shipping costs not included. Errors and price changes excepted
