Anti-Hu Fc epsilon RIa Purified, Clone: [AER-37 CRA1], Monoclonal
Biozol Catalog Number:
EXB-11-959-C100
Supplier Catalog Number:
11-959-C100
Alternative Catalog Number:
EXB-11-959-C100
Manufacturer:
EXBIO
Category:
Antikörper
Application:
FC, ICC, IHC-Fr
Species Reactivity:
Human, Primate
FcepsilonRIalpha serves as the IgE Fc-binding subunit of the high-affinity IgE receptor, expressed on the surface of mast cells and basophils. It associates with one beta and two gamma subunits that contain ITAM sequences in their intracellular domains, that function as docking sites in the process of signalosome forming after FcepsilonRI triggering. Attached IgE gives to the receptor specificity for particular antigens which are target of the type I allergen sensitivity or hypersensitivity reaction, and prolongs stability of the receptor on the cell surface. Under physiological conditions this system protects the body against helminths and other parasites and venom toxins, but when dysregulated, it can lead to undesired allergic reactions and anaphylactic shock.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[AER-37 CRA1]
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Target:
Fc epsilon RIa
Application Notes:
Flow cytometry: Recommended dilution: 1-5 µg/ml.
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