CD184 is a 7-transmembrane G-protein coupled receptor for the C-X-C chemokines SDF-1 (CXCL12), MIG (CXCL9) and IP10 (CXCL10). Alternatively spliced variant CD184B serves as the high affinity receptor for PF4 (CXCL4). CD184 is expressed in hematopoietic cells, vascular endothelium, and neural tissue. It plays important roles in endothelial vascularization and central nervous system development. It can also serve as a primary receptor or a coreceptor for some HIV isolates. CD184 signaling leads to integrin activation, cytoskeletal changes and chemotactic migration.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[rHIQB005]
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Target:
CD183
Application Notes:
Flow cytometry: Recommended dilution: 1-5 µg/ml
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