Purified CD271 protein isolated from human melanoma cell line A875
Conjugation:
Biotin
CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[NGFR5]
Isotype:
Mouse IgG1
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage:
2°C to 8°C
Target:
CD271
Antibody Type:
Monoclonal Antibody
Application Notes:
Flow cytometry: Extracellular and intracellular staining, recommended dilution: 1-4 µg/ml.
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