CD270 is a type I transmembrane protein of the TNFR superfamily, which is expressed on resting T cells, monocytes, and immature dendritic cells. Its ligands, CD258 and CD272, differ in effect on CD270 signaling. Whereas binding to CD258 provides a costimulatory signal, binding to CD272 gives to the cell an inhibitory signal. CD270 also is recognized by herpes simplex glycoprotein D. CD258-CD270 interaction and signaling is implicated in macrophage-derived foam cell-mediated development of atherosclerotic lesions.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[CW10]
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Target:
CD270
Application Notes:
Flow cytometry: Recommended dilution: 1-5 µg/ml.
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