Anti-Hu SIGLEC8 PE, Clone: [7C9], Monoclonal

Product Overview

• Article Name: Anti-Hu SIGLEC8 PE, Clone: [7C9], Monoclonal
• Biozol Catalog Number: EXB-1P-846-T100
• Supplier Catalog Number: 1P-846-T100
• Alternative Catalog Number: EXB-1P-846-T100
• Manufacturer: EXBIO
• Category: Antikörper
• Application: FC
• Species Reactivity: Human
• Immunogen: Extracellular domain of human SIGLEC8 fused with Fc fragment of human IgG1
• Conjugation: PE

Product Description

SIGLEC8 is a sialic acid binding lectin similar to CD33. In its cytoplasmic comain it contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), and a motive similar to a binding site for SLAM-associated protein. SIGLEC8 is expressed e.g. in lymph nodes and spleen. It is an eosinophil marker, although it can be found also on the surface of mast cells. Crosslinking of SIGLEC8 leads to apoptosis. Soluble form of SIGLEC8 can be foud in human serum, especially in case of eosinophil-associated diseases.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [7C9]
• Isotype: Mouse IgG1
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Target: SIGLEC8
• Antibody Type: Monoclonal Antibody

Application Notes

• Application Dilute: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
• Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.