Anti-Hu CD105 Alexa Fluor 488, Clone: [MEM-229], AF488, Monoclonal

Product Overview

• Article Name: Anti-Hu CD105 Alexa Fluor 488, Clone: [MEM-229], AF488, Monoclonal
• Biozol Catalog Number: EXB-A4-453-T100
• Supplier Catalog Number: A4-453-T100
• Alternative Catalog Number: EXB-A4-453-T100
• Manufacturer: EXBIO
• Category: Antikörper
• Application: FC, ICC, IHC-Fr
• Species Reactivity: Human, Porcine
• Immunogen: Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
• Conjugation: AF488

Product Description

CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [MEM-229]
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Target: CD105

Application Notes

• Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.