CD127, a 60-90 kDa type I transmembrane glycoprotein, serves as the alpha subunit of the IL-7 receptor. It heterodimerizes with CD132, which is the common interleukin receptor gamma chain. CD127-mediated signaling promotes cell survival and is essential for lymphocyte development, including V(D)J recombination. Defects in CD127 can cause severe combined immunodeficiency (SCID). It is expressed in common lymphoid progenitors, B and T cell precursors (except CD4/CD8 double positive thymocytes), and mature T cell subpopulations. Majority of CD127-CD4+ T cells are Treg cells.
Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
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