Chemical Name: 3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one
VEGFR / PDGFR kinase inhibitor
Molecular Weight:
264.33
Purity:
98% by TLC NMR conforms
Form:
Orange solid
CAS Number:
[5812-07-7]
Formula:
C17H16N2O
Application Notes:
Potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 µM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04 µM). Also inhibits PDGFR kinase (IC50 = 19.4 µM).
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