Tesmilifene HCl, CAS [[92981-78-7]]

Product Overview

• Article Name: Tesmilifene HCl, CAS [[92981-78-7]]
• Biozol Catalog Number: FBM-10-1085
• Supplier Catalog Number: 10-1085
• Alternative Catalog Number: FBM-10-1085-5MG, FBM-10-1085-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N,N,-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine hydrochloride. Alternate Names: BMS-217380-01, YMB1002, DPPE HCl

Product Description

Anti-estrogen, Chemo-potentiating agent

Product Properties

• Molecular Weight: 319.87
• Purity: >98% by TLC, NMR Conforms
• Form: White solid
• CAS Number: [92981-78-7]
• Formula: C19H25NO

Application Notes

• Application Notes: Tesmilifene, an analog of tamoxifen, acts as a chemopotentiator and antineoplastic agent and was developed for the treatment of breast cancer but never marketed.1 It binds with high affinity to the anti-estrogen binding site (AEBS) in rat liver microsomes but does not bind to the estrogen receptor (at or below 10 µM) .2 Displaces histamine from AEBS, an activity which correlates with its cytotoxic effects on breast cancer cells.2 Enhances the cytotoxicity of taxol, epirubicin, doxorubicin and vinorelbine in multidrug resistance cell lines.3 It has been shown to increase the permeability of the blood-brain and blood-glioma barrier in culture and animal models by modifying brain endothelial functions.4