Aclacinomycin A HCl, CAS [[75443-99-1]]

Product Overview

• Article Name: Aclacinomycin A HCl, CAS [[75443-99-1]]
• Biozol Catalog Number: FBM-10-1099
• Supplier Catalog Number: 10-1099
• Alternative Catalog Number: FBM-10-1099-1MG,FBM-10-1099-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Aclarubicin hydrochloide

Product Description

Proteasome inhibitor

Product Properties

• Molecular Weight: 848.33
• Purity: 95% by TLC, NMR Conforms
• Form: Orange solid
• CAS Number: [75443-99-1]
• Formula: C42H53NO15 HCl

Application Notes

• Application Notes: Specific inhibitor of the 20S proteasome chymotrypsin-like activity1. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells ) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process2. Induces the differentiation of K562 cells towards the erythroid pathway3. Induces apoptosis4. Cell permeable.