Chemical Name: N-(2,6-Dioxo-3-piperidinyl)phthalimide, racemic
E3 UB ligase inhibitor
Molecular Weight:
258.25
Purity:
98% by TLC, NMR Conforms
Form:
White solid
CAS Number:
[50-35-1]
Formula:
C13H10N2O4
Application Notes:
Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution, compound is teratogenic.
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