Chemical Name: 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, hydrobromide
Acetylcholinesterase inhibitor
Molecular Weight:
368.27
Purity:
99% by HPLC, NMR (Conforms)
Form:
Lyophillized solid
CAS Number:
[1953-04-4]
Formula:
C17H21NO3 HBr
Application Notes:
Long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM1. Allosteric potentiator at neuronal nicotinic ACh receptors2. Prevents beta-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells3. Clinically useful agent for symptomatic relief of Alzheimers disease but fails to prevent progression of the disease4,5.
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