Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1- oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
MetAP-2 inhibitor
Molecular Weight:
458.54
Purity:
95% by TLC, NMR (Conforms)
Form:
Orange solid
CAS Number:
[23110-15-8]
Formula:
C26H34O7
Application Notes:
Fumagillin is a natural product isolated from the microbial organism Aspergillus fumigatus and used as an antimicrobial for honey bees. It covalently binds and inhibits methionine aminopeptidase-2.1 Fumagillin also inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo.2
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