Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
TrkB agonist/neurotrophic
Molecular Weight:
254.25
Purity:
98% by TLC, NMR Conforms,
Form:
Yellow or tan solid
CAS Number:
[38183-03-8]
Formula:
C15H10O4
Application Notes:
A selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity.1,2 Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the well-characterized N171-82Q Huntingtons disease mouse model.3 Post-traumatic brain injury-treatment promotes neurogenesis in the hippocampus in a mouse model.4 Improves motor performance and motor neuronal survival in an ALS mouse model.5
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