Chemical Name: 2-Phenylethynesulfonamide. Alternate Names: PES, NSC-303580
Hsp70 inhibitor
Molecular Weight:
181.21
Purity:
98% by TLC, NMR (Conforms)
Form:
White or off-white solid
CAS Number:
[64984-31-2]
Formula:
C8H7NO2S
Application Notes:
Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. Inhibits p53 binding to antiapoptotic proteins Bcl-xL and Bcl-2. Recues primary mouse thymocytes from P53-mediated apoptosis induced by radiation. Cell permeable.
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