PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 µM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 µM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
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