PIT-1, CAS [[53501-41-0]]

Product Overview

• Article Name: PIT-1, CAS [[53501-41-0]]
• Biozol Catalog Number: FBM-10-1192
• Supplier Catalog Number: 10-1192
• Alternative Catalog Number: FBM-10-1192-10MG, FBM-10-1192-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

Product Description

PH domain antagonist

Product Properties

• Molecular Weight: 351.76
• Purity: 98% by TLC, NMR (Conforms)
• Form: Grey solid
• CAS Number: [53501-41-0]
• Formula: C14H10ClN3O4S

Application Notes

• Application Notes: PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 µM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 µM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.