GSK-1016790A, CAS [[942206-85-1]]

Product Overview

• Article Name: GSK-1016790A, CAS [[942206-85-1]]
• Biozol Catalog Number: FBM-10-1198
• Supplier Catalog Number: 10-1198
• Alternative Catalog Number: FBM-10-1198-5MG, FBM-10-1198-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide

Product Description

TRPV4 channel blocker

Product Properties

• Molecular Weight: 655.62
• Purity: 98% by TLC, NMR (Conforms)
• Form: white solid
• CAS Number: [942206-85-1]
• Formula: C28H32Cl2N4O6S2

Application Notes

• Application Notes: A novel and potent TRPV4 channel agonist. GSK1016790A induced Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300-fold more potent than 4alpha-PDD and is a valuable tool for investigating the role of TRPV4 in physiological processes.